How to control the hypertension of patients with chronic nephritis?

Chronic nephritis, the residual and (or) had lesions of the renal unit in compensatory hemodynamic status, systemic hypertension will undoubtedly add to this condition, leading to glomerular injury, and therefore patients with chronic nephritis should be actively controlled high blood pressure, prevent deterioration of renal function.
In recent years, through a series of studies confirmed that most scholars have angiotensin converting enzyme inhibitors as first-line antihypertensive drugs. Lately, a lot of clinical studies confirmed that calcium antagonists such as nifedipine, nicardipine equal treatment of hypertension and renal function deterioration is more positive effect.That calcium antagonists, despite the slight expansion of the role of afferent arterioles, but it has significantly reduced the role of systemic blood pressure, so make the uninvolved or only partially involved glomerular hemodynamics, the high metabolic statusbe improved; In addition, calcium channel blockers reduce oxygen consumption, inhibition of platelet aggregation through the membrane effect of reducing the excessive oxidation of the calcium in the interstitial deposition and reduce the cell membrane, so as to achieve to reduce kidney damage and stable renal function. Clinical reports, short-term (4 weeks) or long (1-2 years) with calcium antagonist treatment of nephritis in patients with chronic renal insufficiency has not revealed any glomerular injury, but clearly demonstrated that it is angiotensin converting enzyme inhibitors is very similar to the efficacy of renal function deterioration. And angiotensin converting enzyme inhibitors at lowering urinary protein role for it in general. It should be noted that some scholars believe that the calcium antagonists impact on renal function is still a need for more long-term observation.
β-blockers, such as the United States and more peace of mind, Atenolol, has a good effect on the renin-dependent hypertension. beta-blockers reduce renin, although the drug reduce cardiac output, but does not affect renal blood flow and GFR, it is also used for the treatment of renal hypertension. It should be noted that some beta-blockers such as atenolol and naphthalene hydroxyl peace of mind, low-fat-soluble, since renal excretion, so renal insufficiency should pay attention to adjust the dose and extending administration time.
In addition, vasodilators such as hydralazine antihypertensive effect, it can be combined with beta-blockers reduce vasodilators stimulate renin  angiotensin system side effects (such as rapid heartbeat, water and sodium retention ), and may improve the therapeutic effect. Hydralazine general daily 200mg, but must be alert to the possibility of drug-induced lupus erythematosus-like syndrome.
Edema renal, can add to a thiazide diuretic; poor renal function (serum creatinine> 200μmol / L), thiophene triazine efficacy or invalid, it should use loop diuretics marrow .Chronic nephritis patients treated with diuretics should be noted that the electrolyte imbalance in the body, and to pay attention to the tendency to aggravate hyperlipidemia, hypercoagulable state.