IgA nephritis should be treated?

IgA nephritis should be treated?
The traditional method of treatment of IgA there is no satisfactory treatment options. Of the disease associated with renal insufficiency adrenal corticosteroids with or without immunosuppressants results are not consistent. Recent data suggest that the proteinuria of more than 1g / d, and subjected to every other day medication adrenal cortex hormone beneficial to the improvement of proteinuria. IgA deposition of minimal change nephropathy may alleviate proteinuria. Used in combination with cyclophosphamide, dipyridamole and warfarin to reduce proteinuria and glomerular filtration rate; combined use of cyclosporin A may also reduce proteinuria, and then also reduced creatinine clearance. Efficacy of phenytoin, anti-platelet drugs, the anthocyanin acid disodium diphenyl Sealand due to such drugs is uncertain. Notwithstanding the reports of urokinase may have a role to protect the glomerular filtration rate, but far from conclusive.Recurrent tonsillitis, tonsillectomy may be useful; antibiotics to prevent and treat infections that may be helpful to some acute nephritic syndrome and acute renal failure for the performers. A small series of observations found that the use of fish oil preparations reducing the role of proteinuria and increased glomerular filtration rate.Severe IgA nephropathy (glomerular filtration rate monthly decline 2 ~ 4ml/min) the use of large doses of immune globulin intravenous infusion period, to stop the glomerular filtration rate, improvement of hematuria and proteinuria, but after stopping often relapse.Cases of hypertension and severe proteinuria, glomerular filtration rate of converting enzyme inhibitors may slow down the rate of descent and reduce proteinuria and severe IgA nephropathy, converting enzyme inhibitors are the preferred antihypertensive drugs.Conversion of normal blood pressure, whether effective inhibitors is unclear.
End-stage IgA nephropathy in a kidney transplant, the transplanted kidney happen soon mesangial IgA deposition; subclinical IgA nephropathy if the donor kidney for renal mesangial IgA deposits after implantation of non-IgA nephropathy uremia often rapidly disappearing. Renal transplantation with recurrence does not necessarily progressive renal failure in IgA nephropathy, however Shi after renal transplantation immunosuppressive therapy including cyclosporine A also did not prevent its development. Cadaveric renal transplantation, 1 year and 3-year graft survival up to 87% and 77%, however, individual IgA antibody IgA anti-HLA antigens of renal transplant recipients, 2-year graft survival of up to 100%. reason to believe that these antibodies against HLA antigens played a useful role in increasing graft survival.