Immunology of the lupus nephritis nine check

1, the general inspection: the majority of patients (80%) moderate anemia (positive cells are hypochromic anemia), even showed hemolytic anemia, thrombocytopenia, 1/4 patients with pancytopenia 90% ESR. Patients globulin significantly increased.
2, the immunological tests
(1) antinuclear antibodies: anti-nuclear antibody test sensitivity of 90% or more, but the specificity is lower in mixed connective tissue disease, rheumatoid arthritis, Sjogren's syndrome, etc. can be positive results. Therefore this experiment can not be used as a diagnosis only indicator may be used as the reference indicator of disease activity, but its titer and kidney involvement or not, and severity.
(2) anti-double stranded DNA antibodies: one of the marker antibodies for diagnosis of SLE, sensitivity 72%, its titer is closely related to lupus activity. Only, even in Sjogren's syndrome, rheumatoid arthritis and activity of hepatitis was positive.
(3) anti-Sm antibodies and anti-RNP antibodies: anti-Sm antibodies found in 25% -40% of patients with this disease, anti-RNP antibodies found in the 26% -45% of the patients.Anti-Sm antibodies in the diagnosis of systemic lupus erythematosus-specific high.
(4) anti-histone antibodies: found in 25% -60% of patients. Specificity is also good, even seen in rheumatoid arthritis and Sjogren's syndrome.
(5) anti-SSA and anti-SSB antibodies: the former is seen in 30% -40%
Patients, only 0-15% of the latter. Both antibodies were mainly seen in Sjogren's syndrome.
(6) other antibodies: SLE, there are a variety of other autoantibodies such as anti-erythrocyte antibodies in hemolytic anemia, and necrotizing vasculitis neutrophil cytoplasmic antibody (ANCA). In recent years, especially great importance of antiphospholipid antibodies, seen in 34% of the patients.
⑺ complement: the C3, C4, and of CH50 can be reduced, especially C3 decline in the judgment of lupus activity, a sensitive and reliable indicators.
(8) skin lupus band: the epidermis and dermis link at the non-lesional skin by direct immunofluorescence can check an IgG and (or) C3 were granular calm yellow-green fluorescence band. Found in more than 70% of patients with this disease.
(9): rheumatoid factor (RF), cryoglobulin test in disease activity were positive.
In summary, the above described method of examination of lupus nephritis allows people to better diagnosis of lupus nephritis, lupus nephritis patients but also to eat more fruits and vegetables, do not eat spicy spicy food appropriate exercise and strengthen its own resistance.