Angiotensin converting enzyme inhibitors for patients with chronic nephritis What is the significance?

In recent years by a large number of animal experiments and nephritis in patients with controlled clinical observation has been confirmed, unless there are certainly antihypertensive efficacy of the drug can reduce glomerular pressure, there is certainly delay the deterioration of renal function, lower urinary protein (20% to 40%) and reduce the role of glomerular sclerosis. Commonly used preparations the mercapto tensiomin proline acid, typical doses of 25 to 50 mg / 3 times a day, clinical; without thiol according to Na Puli, the long duration of action, the commonly used dose of 5 to 10 mg / day 1.The drugs to reduce the main mechanism of ball pressure, protect and stabilize the renal function as follows:
① The expansion of glomerular artery, small arteries of the ball is more significant than the afferent artery dilation, and therefore reduce the pressure inside the ball, reducing renal ball high blood dynamics;
② The angiotensin II-stimulated proximal tubular ammonium, class preparation can reduce the angiotensin II level and (or) l hyperkalemia and reduce the production of ammonium, will help reduce the renal hypertrophy and avoid excessive ammonium generated by the alternative pathway activation of complement induced tubulointerstitial lesions.
The application of such agents should pay attention to can cause hyperkalemia (especially renal dysfunction), other side effects include rash, itching, fever, flu-like symptoms, diminished sense of taste and rare granulocytes reduce. Some people think that class preparation may cause acute drug-induced interstitial nephritis.