Early symptoms of diabetic nephropathy

A medical history and symptoms of diabetes, kidney damage, clinical manifestations and the degree of glomerular sclerosis was positively correlated. Microalbuminuria, history of diabetes has more than 5 to 6 years, clinical diagnosis of early diabetic nephropathy, no clinical manifestations; about 80% of patients within 10 years the development of clinical diabetic nephropathy, ie, urinary protein excretion greater than 0.5g / 24h, usually without significant hematuria, the clinical manifestations of edema, hypertension; Once persistent proteinuria associated with loss of appetite, nausea and vomiting, anemia, suggesting that has chronic renal insufficiency.
Second, the examination revealed varying degrees of hypertension, edema, can occur in severe ascites, pleural effusion, etc.. Multi-merge of diabetic retinopathy.
Third, laboratory examinations
(A) The urine qualitative A simple method for screening of diabetes in diabetic nephropathy, there may be a false negative or false positive, so the blood glucose is the main basis of diagnosis.
(B) urinary albumin excretion rate (UAE) 20 ~ 200μg/min, is an important indicator for early diagnosis of diabetic nephropathy; when the UAE continued to be greater than 200μg/min or routine examination of urinary protein (urinary protein greater than 0.5g/24h), the diagnosis of diabetic nephropathy. Urinary sediment change is not obvious in general, more white blood cells, prompted urinary tract infections; a large number of red blood cells, suggesting that there may be other causes of hematuria.
(C) of diabetic nephropathy with advanced, endogenous creatinine clearance rate and blood urea nitrogen, creatinine increased.
(D) of the radionuclide dynamic renal glomerular filtration rate (GFR) to increase and B-ultrasound measurement of renal volume increases, consistent with early diabetic nephropathy. GFR was significantly decreased in uremic kidney volume is often no obvious narrowing.
(E) fundus examination, if necessary, for fluorescence fundus contrast, the visible micro-aneurysms and other diabetic retinopathy.

What are the methods of Chinese medicine treatment of diabetic nephropathy

①diabetic nephropathy TCM treatment should be heat and dampness, promoting blood circulation. In the basic treatment (including blood sugar control, treatment of hypertension, low salt, high-quality low-protein diet) at the same time with the TCM syndrome differentiation, treatment of diabetic nephropathy, the rational application of Qingrejiedu Dampness, eliminate and alleviate the damp heat evil, inhibition of renal immune inflammation, reduce proteinuria and to promote the repair of kidney disease, thereby improving renal function, and control the progress of this disease have a positive role. Focus on blood circulation in the treatment, especially patients with chronic illness, emphasizing the chronic illness must be active.
② TCM treatment of diabetic nephropathy in drug administration, on the one hand, should pay attention to adjust the patient's immune function, Chinese medicine is the benefit of drug application, for example, can be used: qi ginseng, Astragalus, Codonopsis, Sijunzitang, Buzhongyiqitang. The nourishing Class cinnamon, pilose antler, Cordyceps sinensis, Psoralea, Cistanche, Ba Wei Di Huang balls. On the other hand, should be taken to avoid the use of renal toxic effects of traditional Chinese medicine, such as manshuriensis Han fangchi, cantharidin, bee venom, motherwort.
③ diabetic nephropathy (DN), Western medicine in the treatment of certain limitations and adverse effects, especially long-term use will have considerable side effects in the liver and kidney more than eight years. Chinese medicine syndrome is a means of effective prevention and treatment of diabetic nephropathy. The man in the field of prevention and treatment of diabetic nephropathy concern, especially the advantages of the good efficacy in the prevention and treatment of early diabetic nephropathy and reduce adverse reactions, making it an important means of intervention.
These are the traditional Chinese medicine treatment of diabetic nephropathy in patients with diabetic nephropathy, their islet and kidney cells are subject to damage. Targeting Chinese living pancreatic infiltration therapy by drugs active ingredients fully release and mixed after the effective penetrant and infiltration devices, the active ingredients of drugs enter the lesion, in order to repair the damaged cells, so that diabetes re-kidney patients with insulin secretion, and elimination of insulin resistance; targeting Chinese medicine living pancreatic infiltration therapy to repair damaged kidneys, blocking and reversal of renal fibrosis cells, maximum repair the kidneys, so that diabetic nephropathy The patients gradually recover.

The Best Time for Treating Diabetic Nephropathy

Diabetic Nephropathy is one of the most common complications of Diabetes. It is also a major cause of death in patients with Diabetes. When it is caught in the early stages, its progression may be slowed with treatment. Once large amounts of protein appear in the urine, the patients' condition will slowly get worse. Often, it will lead to Kidney Failure. Therefore, choosing the best time for treating Diabetic Nephropathy is of great importance. Then, when is the time for treating Diabetic Nephropathy?
Actually, in treating Diabetic Nephropathy, the earlier the treatment is, the better the curative effect will be, for with the worsening of the kidney damages, the treatment and the prognosis will correspondingly become more difficult.
Both the occurrence and the development of Diabetic Nephropathy are the process of the accumulation of kidney damages. Clinically, Diabetic Nephropathy can be divided into five stages. Generally, if the blood sugar did not get good control, Type 1 Diabetes will progress one stage every five years, while Type 2 Diabetes will progress one stage every three or four years.
Stage 1 to Stage 3 all belong to the early stage of Diabetic Nephropathy. In these three stages, usually there is no symptoms. If effective treatment can be adopted in these stages, Stage 1 Diabetic Nephropathy can be cured, while the progression of Stage 2 or 3 Diabetic Nephropathy can be obviously suppressed. In stage 1, only the glomerular filtration rate(GFR) increases, therefore, if the blood sugar can be controlled well, the patients' condition can be reversed. In stage 2 and 3, microalbumin will occur in the urine. If the microalbumin only occurs after exercise, fever or in other stress state, it is stage 2 Diabetic Nephropathy; if the microalbumin occurs persistently, it is stage 3 Diabetic Nephropathy. In treating stage 2 and 3 Diabetic Nephropathy, apart from controlling the blood sugar, angiotensin converting enzyme inhibitor(ACEI) and angiotensin receptor blockers(ARB) should also be adopted.
By urine routine test, if the urine protein is positive, it indicates the coming of stage 4 Diabetic Nephropathy. In this stage, the urine protein will increase and finally form large quantities of proteinuria(the urine protein is more than 3.5 g/d), which will lead to hypoproteinemia, edema and hyperlipidemia. That is to say, patients with stage 4 Diabetic Nephropathy will have Nephrotic Syndrome, often with hypertension. At this time, the renal function will get worse quickly. And as for treatment, it is mainly symptomatic treatment, including limiting the salt intake, promoting the urination, lower the blood pressure and regulating the blood lipid.
If the patients' condition continue to worsen, it will develop into the stage 5 Diabetic Nephropathy—the Kidney Failure period. In this stage, the patients will have poor appetite, nausea, vomit and other symptoms, and their serum creatinine and blood urea nitrogen will increase. And finally, in order to sustain life, dialysis will be necessary for some patients.
From the above, we can conclude that stage 1 to stage 3 is the best time for prolonging the progression of Diabetic Nephropathy.