What is a membranous nephropathy

What is membranous nephropathy, a? Believe that a lot of friends do not quite understand, membranous nephropathy is kidney disease a membranous nephropathy isdivided into several phases, each phase has its own features, here we come tounderstand.
What is membranous nephropathy, a? Believe that a lot of friends do not quite understand, membranous nephropathy is kidney disease a membranous nephropathy isdivided into several phases, each phase has its own features, here we come tounderstand. In the understanding of the what is a membranous nephropathy,membranous nephropathy, membranous nephropathy, we briefly introduced the generalwas nephrotic syndrome (proteinuria, hypoalbuminemia, hyperlipidemia, high degree ofedema) or asymptomatic proteinuria. Membranous nephropathy, pathological changesare generally glomerular capillary loops, immune complexes in the epithelial cell calmcharacterized, followed by basement membrane thickening and deformation, the generalnon-proliferation of mesangial, endothelial or epithelial cells or cells infiltration.Immunofluorescence IgG and C3 showed diffuse and uniform granules along thebasement membrane distribution, rare IgM and IgA calm. Membranous nephropathy inseveral specific pathological changes as follows: ① accompanied by more pronouncedmesangial proliferation and mesangial matrix expansion; ② accompanied by interstitiallesions; ③ of the disease associated with glomerular progressive, segmentalhyalinization sclerosis, accompanied by interstitial fibrosis; ④ of the disease can be transformed into a crescent body nephritis type Ⅰ; ⑤ The occasional disease withmesangial IgA dominant immune pathological changes, namely, overlappingmembranous nephropathy and IgA nephropathy performance. A membranous nephropathy, membranous nephropathy, a number of pathological variant is lighter, onlymesangial proliferation, mesangial matrix increase, and the absence of interstitial,glomerular stage of hyalinization as well as the crescent, you renal biopsy puncture reportfully proved consistent with a membranous nephropathy.

Membranous nephropathy etiology

The exact cause of this disease is not yet clear, Clinical according to their causes can be divided into primary MN and secondary MN two categories. The former is of unknown etiology, the latter because it often accompanied by autoimmune diseases such as systemic lupus erythematosus, the incidence of hepatitis B and C, is now generally believed that the disease exist autoimmune abnormalities. Secondary causes of membranous nephropathy caused by:
An autoimmune disease systemic lupus erythematosus, rheumatoid arthritis, diabetes, Hashimoto's thyroiditis, Graves disease, mixed connective tissue disease, Sjogren syndrome, primary biliary cirrhosis, ankylosing spondylitis and acute infectious polyneuritis.
(2) infected with hepatitis B, hepatitis C, syphilis, leprosy, filariasis, schistosomiasis and malaria.
Drugs and toxic organic gold, mercury, D-penicillamine, captopril and probenecid.
Tumors of lung cancer, colon cancer, breast cancer and lymphoma.
Sarcoidosis, graft recurrence of sickle cell disease and angiolymphoid hyperplasia (Kimura disease). 75% of membranous nephropathy can not find the above reasons, that is, belonging to idiopathic membranous nephropathy.