Symptoms of chronic glomerulonephritis

Chronic nephritis is diverse etiology, pathological and clinical manifestations similar to a group of glomerular diseases, they are common manifestations of edema, hypertensionand urinary abnormalities.
Edema: (1) in the whole course of the disease, most patients with varying degrees ofedema. Edema can be can be light weight, light in only the morning from the chronic nephritis edema found in the performance of the bed, around the eyes, facial swelling, or in the afternoon of both lower extremities ankle edema. Patients with severe, generalized edema. However, there are a very small number of patients throughout the course of the disease do not always appear edema, is often easily overlooked.
(2) high blood pressure: some patients are hypertension symptoms to hospital for treatment, doctors want them to laboratory urine, chronic nephritis caused by high blood pressure. For patients with chronic nephritis, the incidence of hypertension is one sooner or later, their blood pressure can be continuous, intermittent, and diastolic blood pressure (higher than 12.7kPa) is characterized by high blood pressure there are greatindividual differences in the degree of light only 18.7-21.3/12.7-13.3kPa, severe casescan even be more than 26.7/14.7kPa.
(3) urinary abnormalities: abnormal urine is almost a must in patients with chronic nephritis, including urine output changes and microscopic abnormalities. Edema in patients with decreased urine output, and the more severe edema, decreased urine output, the more obvious, and no edema in patients with normal urine majority. Whenpatients with kidney serious damage, urine concentration - dilution of functional disorder, but also increased nocturia and urine specific gravity decreased. The urine of patients with chronic nephritis put under the microscope, you can find almost all of the patients had proteinuria, urinary protein content ranging from (±) to (). Urine can see the levelranging from red blood cells, white blood cells, granular casts, transparent tube. Whenthe acute attack, may have significant hematuria, or even gross hematuria. In addition,patients with chronic nephritis also dizziness, insomnia, anorexia Shenpi fatigue,impatience, and varying degrees of anemia and other clinical symptoms.

Concrete manifestation of acute and chronic nephritis symptoms

Concrete manifestation of the symptoms of acute and chronic nephritis, a lot of people heard of this disease, but specific to the disease what the performance is not clear, which makes many people sick without knowing it, until the discovery condition is very serious? because they missed the best time for treatment to regret it.
Mainly acute and chronic nephritis symptoms: The disease before the onset of more than a history of scarlet fever, tonsillitis, streptococcal infection, 7 to 21 days after infection onset. Three major characteristics of the symptoms of acute and chronic nephritis
Edema: eyelid edema, a few days later the development of the lower limb and body swelling disappear after 2 to 4 weeks.
2, hematuria: the majority of the dark brown or brown. About two weeks after the disappearance of gross hematuria, microscopic examination of hematuria sustainable for several months.
Hypertension: the majority of mild to moderate blood pressure increases, the performance of headache, dizziness, vomiting, usually last for two weeks, then gradually decreased. In addition, it can also be associated with mild anemia, fatigue and low back pain. In the treatment, such as early detection, and complete bed rest, careful treatment, the prognosis is good.
Expert tips can also refer to the laboratory screening and diagnosis of acute and chronic nephritis symptoms
Urinary protein excretion daily 0.5 ~ 2g/m2; any urine protein / creatinine ratio may be <2 (normal 0.1 to 0.3). Urine contains a shaped red blood cells, white blood cells and renal tubular cells, casts, including red blood cell casts and hemoglobin tube characteristic, the more common white blood cell casts and granular casts (protein droplets).
Anti-pathogenic infectious agent antibody titers are usually 1 to 2 weeks rose. Antibody increase against streptococcal antigen products can be measured: the antistreptolysin prime-O (ASO) is upper respiratory tract infection the best instructions, and pyoderma anti-hyaluronidase and anti-DNase B. usually reduce the disease activity of C3 and C4.Return to normal complement levels in 80% of the PSGN cases 6 to 8 weeks, in fact, one case of mesangial proliferative glomerulonephritis (MPGN) is so. Cryoglobulinemia is often persist for several months, and circulating immune complexes can only be detected within a few weeks.
Tubular function is often due to changes in the disorder of interstitial inflammation, leading to decreased ability to concentrate urine and acid secretion capacity, solute exchange impairment of the renal unit. Has some intrinsic glomerular hypertrophy and the ability of tubular function defects is usually occurs before the GFR was significantly reduced. With the gradual progress of glomerular dysfunction, total filtration area was significantly reduced decline in GFR, azotemia appear. GFR can be cleared from the serum creatinine concentration or urine creatinine, estimated rate of GFR is usually returned to normal in 1 to 3 months, proteinuria may last 6 to 12 months, microscopic hematuria for several years. Short-term changes in the urinary sediment of mild upper respiratory tract infection could happen again.
Before the onset of 1 to 6 weeks of this syndrome, there is a history of streptococcal infection, sore throat, impetigo or culture confirmed and the increase can be helpful in the diagnosis of anti-streptococcal antibody titer. Red tube in any glomerulonephritis are visible, but when and clinical manifestations associated, strongly suggestive of acute nephritic syndrome. The ultrasound can help differentiate the acute disease (kidney volume is usually normal or slightly larger) and chronic diseases increased (decreased renal size).
The above symptoms on acute and chronic nephritis, specific to each person will have a gap.