FGS prognosis

Of FSGS and poor prognosis, 25% to 30% and 30% to 40% 5 years and 10 years into the renal failure. 10% to 20% of the pediatric the OK dialysis or renal transplant recipients caused by the disease. The following clinical and laboratory indicators for estimating the prognosis of a certain reference value: (1) Clinical manifestations: non-selective proteinuria may be invalid prednisone severe persistent proteinuria and manifested as nephrotic syndrome is often the H-resistant creatinine level, acute renal failure and poor prognosis. (2) morphological changes: the lesions in the urinary pole that is, state-of-the-art disease, better prognosis, and prognosis of lesions around the vascular pole or the mixed type, the collapse associated with poor outcome. Associated with the development of interstitial fibrosis to the possibility of chronic renal failure. (3) The other accompanied circumstances: racial genetic backgrounds (Africa and Spain, children with poor prognosis, poor prognosis of a positive family history), adult patients, the prognosis is less favorable than those children, human immunodeficiency virus infection and heroin, cocaine, a drug abuser with poor prognosis.

High rates of renal transplantation recurrence of FSGS is generally believed that 25% to 40% recurrence after transplantation, 20% to 50% within five years, once again lose their kidney function, a higher relapse rate in OK kidney transplant again up to 80%. Related kidney transplantation than cadaveric renal higher relapse rate. Recurrence of FSGS often to glucocorticoid resistance, although the report cyclophosphamide (8 to 12 weeks, 1 ~ 2mg * kg-1 * d-1) allows long-term remission [15]. Early plasma exchange could prevent FSGS recurrence remains to be documented.