What is the FSGS kidney disease? What are clinical manifestations of FSGS kidney disease?

Glomerular capillary nephrotic FSGS kidney disease called focal segmental glomerulosclerosis whole, refers to the glomerular capillary loops with focal segmental glomerular sclerosis or hyaline degeneration, no significant cell proliferation. FSGS kidney disease is a common pathological type of primary nephrotic syndrome, the pathological type 50% of patients with nephrotic syndrome FSGS kidney disease, renal biopsy can be clear of the disease.
The disease mostly occurs in children and young people, more men than women, a small number of patients with FSGS kidney disease before the onset of upper respiratory tract infection or allergic reaction history. In addition, the occurrence of FSGS nephrotic familial tendency FSGS kidney disease is relatively common in the atopic population, the main clinical manifestations and characteristics:
(1) The first clinical symptoms of nephrotic syndrome, microscopic to common hematuria, and occasionally gross hematuria in adults is about 2/3 of patients had mild persistent hypertension.
(2) urine routine examination, a small number of patients with FSGS kidney disease is asymptomatic proteinuria. Proteinuria and the vast majority of non-selective, but early high or moderate selectivity.
(3) blood test serum C3 levels were normal, IgG levels decline.
(4) of FSGS kidney patients more than the performance of the proximal renal tubular dysfunction, progressive decline of glomerular filtration rate, upper respiratory tract infection or allergic allows a variety of symptoms get worse.