Children with nephrotic syndrome diagnostic criteria

The nephrotic syndrome is due to increased permeability of the glomerular filtration membrane, leading to a clinical syndrome caused by a large number of plasma albumin is lost in the urine. ?? Has massive proteinuria (qualitative> + + + 24hr quantitative> 50mg/kg); hypoproteinemia (plasma albumin <30g / L); ƒ hypercholesterolemia (blood cholesterol> 5.72mmol / L), ; "varying degrees of edema, four major characteristics. Beijing Military General Hospital, subsidiary Bayi Children's Hospital, Pediatric Nephrology, Huang Jianping variety of primary, secondary, congenital or hereditary glomerular diseases can cause this disease, but children period the vast majority (90%) of the primary.
1 clinical classification
(1) simple type only these four characteristics.
Nephritis (2) In addition to the above conditions, but also with one or more of the following four:?? Hematuria: 2 weeks three times centrifuged urine check, red blood cells> 10 / HPF; recurrent or persistent hypertension, 317.3/12.0kPa school-aged children, preschool> 16.0/10.7kPa, and the exclusion of corticosteroids due; ƒ persistent azotemia, blood urea nitrogen 10.7mmol / L, and the exclusion of hypovolemia due topersons; the total blood complement or C3 repeatedly reduced.
2 pathological type
Common pathological type of minimal change disease (MCD) and non-minimal change disease, the latter including focal segmental glomerulosclerosis (of FSGS), mesangial proliferative glomerulonephritis (MsPGN), membranous nephropathy (MGN) and membrane proliferation of nephritis (MPGN). The children MCD common, followed by FSGS and mild to moderate MsPGN. MGN is rare in the pediatric primary, only 1 to 2 percent, the vast majority of the secondary, especially hepatitis B virus associated glomerulonephritis. MPGN is a more serious type of pathology, and need early diagnosis and treatment in a timely manner.