The disease mostly occurs in children and adolescents, men slightly more than
women.Minority suffering from focal segmental glomerulosclerosis imaging
Persons before the onset of upper respiratory tract infection or allergic reactions. Most common clinical symptom is the nephrotic syndrome, about 2/3 of patients with massive proteinuria and severe edema, urine protein 1 to 30g / d, more than about 50% of patients with hematuria, microscopic hematuria common and occasionally gross hematuria. 30% ~ 50% of the adult patients with mild persistent hypertension or manifestations of chronic nephritic syndrome, patients with 24h urinary protein <3.5g / d, the edema is not obvious, often hematuria, hypertension and renal insufficiency, and 50% was renal comprehensive performance significantly "three high and one low clinical manifestations. A small number of patients with no obvious symptoms, and occasionally found in routine urinalysis proteinuria. This type of asymptomatic proteinuria sustainable a long time, a better prognosis. A small number of patients with this type of gradual development of end-stage renal failure. Proteinuria and the vast majority of non-selective, but early high or moderate selectivity. Serum C3 concentration of normal IgG level decreased. Often proximal tubular function is impaired performance. The above symptoms of upper respiratory tract infections or allergies can make worse. Slight differences in the different pathological types of clinical manifestations of the disease, typical FSGS and glomerular hypertrophy, urinary protein less; cell FSGS often massive proteinuria (> 10g / d), and prone to renal insufficiency. Have reported that 60% of cell FSGS patients with serum creatinine> 2mg/dl, while only 10% of patients in a typical FSGS serum creatinine increased. Collapsing type of FSGS also significant proteinuria, often> 10g / d and renal insufficiency are more serious than other types, and hypertension is relatively small. This type of rapid onset, rapid progression, usually 1 to 2 years after the onset into the end-stage renal failure (ESRF). The clinical manifestations of pediatric patients and adults, mostly with nephrotic syndrome, while the proportion of the occurrence of hypertension and renal insufficiency than in adults is low. The majority (40% ~ 60%) FSGS showed a chronic progressive, eventually leading to kidney failure, a small number of patients (10% to 15%) rapid progress of the disease, earlier onset of renal failure.
if you what to know the most effective treatment for FSGS,please clinic this link
Persons before the onset of upper respiratory tract infection or allergic reactions. Most common clinical symptom is the nephrotic syndrome, about 2/3 of patients with massive proteinuria and severe edema, urine protein 1 to 30g / d, more than about 50% of patients with hematuria, microscopic hematuria common and occasionally gross hematuria. 30% ~ 50% of the adult patients with mild persistent hypertension or manifestations of chronic nephritic syndrome, patients with 24h urinary protein <3.5g / d, the edema is not obvious, often hematuria, hypertension and renal insufficiency, and 50% was renal comprehensive performance significantly "three high and one low clinical manifestations. A small number of patients with no obvious symptoms, and occasionally found in routine urinalysis proteinuria. This type of asymptomatic proteinuria sustainable a long time, a better prognosis. A small number of patients with this type of gradual development of end-stage renal failure. Proteinuria and the vast majority of non-selective, but early high or moderate selectivity. Serum C3 concentration of normal IgG level decreased. Often proximal tubular function is impaired performance. The above symptoms of upper respiratory tract infections or allergies can make worse. Slight differences in the different pathological types of clinical manifestations of the disease, typical FSGS and glomerular hypertrophy, urinary protein less; cell FSGS often massive proteinuria (> 10g / d), and prone to renal insufficiency. Have reported that 60% of cell FSGS patients with serum creatinine> 2mg/dl, while only 10% of patients in a typical FSGS serum creatinine increased. Collapsing type of FSGS also significant proteinuria, often> 10g / d and renal insufficiency are more serious than other types, and hypertension is relatively small. This type of rapid onset, rapid progression, usually 1 to 2 years after the onset into the end-stage renal failure (ESRF). The clinical manifestations of pediatric patients and adults, mostly with nephrotic syndrome, while the proportion of the occurrence of hypertension and renal insufficiency than in adults is low. The majority (40% ~ 60%) FSGS showed a chronic progressive, eventually leading to kidney failure, a small number of patients (10% to 15%) rapid progress of the disease, earlier onset of renal failure.
if you what to know the most effective treatment for FSGS,please clinic this link
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