Of FSGS start the factors

Of FSGS initiation factors not yet elucidated, but most scholars believe that thelymphocyte abnormal activation, release of lymphocyte factor, resulting in abnormalglomerular permeability and sclerosing changes. But results in abnormal glomerular capillary wall permeability and promote hardening factor remains unclear. The reportwould permit the experimental animals the presence of proteinuria lymphocyte-derivedfactor in FSGS patients. Some scholars believe that this cycle can change vascularpermeability factor can cause glomerular epithelial cell foot process fusion, resulting infoot process and basement membrane separation, followed by the basement membranepermeability changes in endothelial protein deposition, vascular loop necrosis, vascular loop and balloon adhesion, typical glomerulosclerosis change to.
Oxide production may be another important pathogenic mechanism observed in animal models of proteinuria, Mn - superoxide dismutase have increased the level of gene transcription in rat renal artery perfusion oxide.
FSGS have different characteristics in different ethnic groups. African-American andSpanish children from FSGS to terminal renal speed faster than the Caucasian, and theratio of the number. Related kidney transplant relapse rate than cadaveric renaltransplantation more, suggesting that genetic background plays an important role of FSGS pathogenic, but the specific genetic markers have not yet been confirmed.